Clinical Use Cases

In the data integration centres (DIC) of the MII, health care data are to be made available for medical research in a data protection-compliant manner. During the consolidation and extension phase, the functionality of the DIC will be tested and further developed in new use cases of the MII. Eight clinical use cases and three methodology platforms are being funded.

In the clinical use cases, the added value of sharing health-related data beyond the boundaries of the consortia in research and healthcare will be tested using medically relevant use cases. The method platforms will address the central technical and methodological needs of the MII consortia across all sites and develop solutions that are fundamental to the cross-site utilisation of data.

For the prevention and treatment of cardiovascular diseases, physicians use so-called risk scores for the individual risk assessment of patients. In the project, routine cardiological clinical documentation shall be structured and standardized across sites. In addition, the infrastructure for automated analysis of biosignal data, such as the ECG, is to be expanded and integrated into the DIC infrastructure at the clinics. These data sources shall be used to improve risk models that can predict the development and course of cardiovascular diseases and thus support better treatment in the future.

The project aims to make clinical data from patients with common eye diseases receiving IVOM (intravitreal drug administration) therapy available for scientific evaluation to improve treatment outcomes. Intravitreal injection involves administering a drug directly into the vitreous humor of the eye. This is intended to preserve or improve vision. An analysis platform will be provided for EyeMatics to integrate data from various inpatient and outpatient care systems.

When patients use many different medications, drug interactions can occur. The aim of INTERPOLAR is to detect these automatically in order to prevent adverse effects. To achieve this, patients with a particularly high risk of medication errors and side effects are identified. In this way, the limited resources of ward pharmacists can be directed to the high-risk patients in order to achieve maximum patient benefit.

The project will help to ensure that the subjective health status of patients (“Patient Reported Outcome”) can be easily measured in all German university hospitals with the help of questionnaires and evaluated together with outcome-relevant clinical parameters. The benefit of this systematic recording will be investigated on the basis of three clinical examples: Patients with anorexia nervosa, with permanent physical complaints and after kidney transplantation.

The project aims to create a permanent infrastructure to integrate and exchange data from clinical and biomedical research. This is to lay the foundation for establishing personalized medicine in cancer treatment.

The goal is to develop and implement a data-driven, risk-stratified infection control system to most effectively and efficiently reduce the number of bacteremias (presence of bacteria in the bloodstream) occurring in the hospital. To this end, an automated surveillance system will be established and validated.

If breathing pauses (apneas) occur during sleep more than five times an hour, this is known as obstructive sleep apnea (OSA). Somnolink aims to optimise patient-centered diagnosis and treatment of OSA. In particular, it aims to improve the detection of OSA among female patients. In addition, decision support systems using artificial intelligence shall provide a better understanding of the individual causes of OSA, the associated health risks and the most suitable therapy.